10 papers analyzed
These studies suggest shadow enhancers maintain robust gene expression, suppress transcription factor noise, and play a crucial role in developmental patterning and gene expression control.
Shadow enhancers are a type of cis-regulatory element that play a crucial role in the regulation of gene expression during development. These enhancers are often found in remote positions relative to the genes they regulate and can produce similar patterns of gene expression as primary enhancers. The study of shadow enhancers has revealed their importance in ensuring robustness and precision in gene expression, particularly under varying environmental and genetic conditions.
Robustness in Gene Expression:
Redundancy and Developmental Precision:
Mechanisms of Action:
Evolutionary Conservation and Prevalence:
Shadow enhancers are essential components of gene regulatory networks that ensure robustness and precision in gene expression during development. They achieve this by buffering against environmental and genetic perturbations, reducing transcriptional noise, and providing redundancy. The prevalence and evolutionary conservation of shadow enhancers highlight their critical role in maintaining stable and precise gene expression patterns, which are vital for proper development.
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