10 papers analyzed
These studies suggest that spermidine is generally safe and well-tolerated, particularly at dietary levels, with potential health benefits including memory function, brain integrity, and protection against various diseases, while also indicating that at supraphysiological doses, it can cause toxicity in certain cell types and laboratory animals.
13 papers analyzed
Spermidine, a naturally occurring polyamine, has been studied for its potential health benefits and safety profile. It is found in various foods and is known for its role in cellular processes such as autophagy. The safety and tolerability of spermidine supplementation have been evaluated in both animal models and human subjects.
The collective findings from the research suggest that spermidine is safe and well-tolerated at concentrations typically found in food and when supplemented in controlled doses in both animal models and humans. It has demonstrated potential health benefits, including protection against various diseases and lifespan extension. However, caution is advised with supraphysiological doses, as they may cause adverse effects. Further research is encouraged to explore the long-term impact of spermidine supplementation on human health.
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