10 papers analyzed
These studies suggest that topical tranexamic acid effectively reduces blood loss and the need for blood transfusions in various surgeries, including total knee and hip replacements, without significantly increasing the risk of complications.
Tranexamic acid (TXA) is a synthetic antifibrinolytic agent commonly used to reduce bleeding in various surgical procedures. While intravenous administration of TXA is well-documented, topical application is gaining attention due to its potential to minimize systemic absorption and associated risks.
Reduction in Blood Loss and Transfusion Rates
Safety Profile
Cost and Length of Hospital Stay
Comparative Efficacy
Topical application of tranexamic acid is effective in reducing blood loss and the need for blood transfusions in various surgical procedures, particularly in orthopedic surgeries like total knee and hip replacements. It offers a favorable safety profile with minimal systemic absorption and reduced risk of thromboembolic events. Additionally, it can lower hospital stay durations and associated costs, making it a practical alternative to intravenous administration. Further research is warranted to explore its efficacy in non-orthopedic surgeries and to determine the optimal dosing for topical use.
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