10 papers analyzed
These studies suggest zinc supplementation may reduce depressive symptoms and improve the efficacy of antidepressant drugs, though more research is needed to confirm its effectiveness as a monotherapy.
16 papers analyzed
Zinc is an essential trace mineral involved in numerous biological processes, including brain function and neural structure maintenance. Recent research has explored the potential role of zinc supplementation in the prevention and treatment of depression, a significant public health issue.
Zinc Supplementation and Antidepressant Efficacy:
Zinc Monotherapy:
Dietary Zinc Intake and Depression Risk:
Zinc Deficiency and Depression:
Mechanisms of Action:
The collective evidence suggests that zinc supplementation can be beneficial in reducing depressive symptoms, particularly when used alongside conventional antidepressant therapies. Zinc monotherapy also shows promise, especially in individuals with higher baseline depression scores. Additionally, higher dietary zinc intake is associated with a reduced risk of developing depression. The underlying mechanisms likely involve zinc's role in neurotransmitter regulation and neurotrophic support. Further research is needed to confirm these findings and optimize zinc supplementation strategies for depression treatment.
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