systemic lupus erythematosus

Introduction

Systemic lupus erythematosus (SLE) is a complex, chronic autoimmune disease that can affect multiple organ systems, including the skin, joints, kidneys, and central nervous system. The pathogenesis of SLE involves a multifactorial interplay of genetic, environmental, and hormonal factors, leading to immune dysregulation and autoantibody production.

Key Insights

Genetic and Environmental Factors:
- SLE is influenced by genetic susceptibility and environmental triggers such as UV light and Epstein-Barr virus infection .
- Rare, inherited single-gene complement deficiencies are strongly associated with SLE, but the disease is typically polygenic .
Immune Dysregulation:
- The disease involves aberrations in both the innate and adaptive immune systems, including dysregulation of cytokines, T cells, B cells, and macrophages .
- Autoantibody production against nuclear and cytoplasmic antigens is a hallmark of SLE .
Clinical Manifestations:
- SLE presents with a wide range of symptoms, including skin rashes, arthritis, glomerulonephritis, and neuropsychiatric involvement .
- The disease course is characterized by periods of remission and relapse.
Diagnosis and Challenges:
- Diagnosis is primarily clinical and remains challenging due to the heterogeneity of the disease .
- Late diagnosis and treatment-resistant disease are significant challenges, contributing to increased morbidity and mortality .
Therapeutic Advances:
- Significant therapeutic advances have been made, including the approval of belimumab and the use of mycophenolate mofetil and glucocorticoid-sparing regimes .
- Newer biological therapies targeting specific cells and molecules involved in SLE pathogenesis are being developed, although their precise roles are still being established .
Complications and Management:
- SLE patients are at increased risk of premature cardiovascular disease and infections due to immunosuppressive therapy .
- Management includes general measures like sun protection, diet, and exercise, as well as organ-specific treatments with steroids, immunosuppressive agents, and biologics.

Conclusion

Systemic lupus erythematosus is a multifaceted autoimmune disease influenced by genetic, environmental, and hormonal factors, leading to complex immune dysregulation. Despite significant therapeutic advances, challenges remain in diagnosis, treatment-resistant disease, and managing complications. Continued research into the underlying mechanisms and development of targeted therapies holds promise for improved outcomes in SLE patients.

Systemic lupus erythematosus

Summary

Introduction

Key Insights

Conclusion

Sources and full results

Systemic lupus erythematosus.

Systemic lupus erythematosus is a complex multisystem autoimmune disorder with multifactorial pathogenesis, highlighting the need for further understanding of underlying immune mechanisms.

Systemic lupus erythematosus

Newer therapies and stem cell techniques may offer better outcomes for systemic lupus erythematosus, but challenges remain in diagnosis, treatment resistance, and potential cures.

Systemic lupus erythematosus

Systemic lupus erythematosus is a complex disorder with diverse clinical features and causes, and new targeted biological approaches show promise for improved treatment.

Systemic lupus erythematosus.

Recent investigations into the immunoregulatory disturbances underlying systemic lupus erythematosus provide insights into diagnosis and treatment approaches.

Systemic lupus erythematosus.

Systemic lupus erythematosus in children and adolescents presents with diverse clinical patterns and outcomes, requiring individualized treatment approaches.

Systemic lupus erythematosus.

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects various organs of the body, especially the skin, joints, blood, kidneys, and central nervous system.

Mutation of DNASE1 in people with systemic lupus erythematosus

Low activity of DNASE1 is directly linked to the progression of human systemic lupus erythematosus.

Systemic lupus erythematosus in children and adolescents.

Systemic lupus erythematosus (SLE) in children and adolescents can cause significant morbidity and mortality, and requires specialized pediatrician care.

Systemic lupus erythematosus: epidemiology, pathophysiology, manifestations, and management.

Systemic lupus erythematosus is a chronic autoimmune disorder affecting various organs, with various symptoms and management strategies based on disease activity and severity.

Pathogenesis of Human Systemic Lupus Erythematosus: A Cellular Perspective.

The pathogenesis of systemic lupus erythematosus involves complex interactions of genetics, environment, and hormones, requiring tailored therapeutic approaches to overcome its complex mechanisms.

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