9 papers analyzed
These studies suggest that vitamin A (Retinol) is generally safe at certain dosages and forms, with long-term daily consumption of up to 7500 retinol equivalents being safe in adults with specific conditions, and up to 30,000 IU being safe for topical use and in pregnant women, but caution is advised with water-miscible, emulsified, and solid forms due to higher toxicity, and high doses can lead to developmental toxicity, while liver products may lead to higher plasma concentrations of retinoic acid metabolites in pregnant women.
8 papers analyzed
Vitamin A, also known as retinol, is an essential nutrient important for vision, growth, cell division, reproduction, and immunity. Vitamin A supplementation is used to treat certain health conditions, but its safety, particularly at high doses, has been a subject of research.
Key Insights from Research Papers:
Conclusion:
Vitamin A is generally safe when consumed at recommended levels. Long-term intake below 25000 IU/day does not show signs of toxicity in adults, and topical applications do not significantly alter plasma vitamin A levels. However, the form of vitamin A supplementation can affect its toxicity, with oil-based preparations being less toxic than water-miscible, emulsified, or solid forms. Pregnant women should be cautious with vitamin A intake, especially from liver products, due to the potential for higher plasma concentrations of retinoic acid metabolites. Overall, vitamin A can be safely incorporated into diets and therapeutic regimens within established guidelines.
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