DMSO: Uses and Risks

This post was written with Consensus AI Academic Search Engine – please read our Disclaimer at the end of this article. Dimethyl sulfoxide (DMSO) is a versatile compound with a range of applications in medical treatments. It is known for its excellent penetrating properties and ability to act as a hydroxyl antioxidant, which can inhibit leukocyte adherence. Despite its benefits, DMSO also presents certain risks that need to be considered in its application.

Medical Uses of DMSO

Pressure Ulcer Prevention

DMSO has been studied for its potential role in preventing pressure ulcers (PU). A randomized, double-blind study investigated the effects of a 5% DMSO cream applied topically to patients at risk for PU. While the study found no significant difference in PU incidence on the buttocks, an unexpected increase in superficial pressure ulcers was observed at the heel location, suggesting a possible adverse effect in certain areas1.

COVID-19 Prevention

During the COVID-19 pandemic, a study explored the use of a nasal spray combining DMSO and ethanol to protect healthcare workers. The results indicated a significant reduction in the incidence of COVID-19 among those using the spray compared to a control group, suggesting that DMSO may have protective effects against viral infections when used in combination with other substances2.

Treatment of Acute Tendopathies

DMSO has also been used in the treatment of acute tendopathies, such as periarthropathia humeroscapularis and lateral epicondylitis. A multicenter, placebo-controlled study demonstrated that a 10% DMSO gel significantly improved pain and joint mobility compared to a placebo. The treatment was well-tolerated, with a high percentage of patients reporting no adverse effects3.

Interstitial Cystitis/Painful Bladder Syndrome

In the treatment of interstitial cystitis/painful bladder syndrome (IC/PBS), DMSO has been compared to other treatments like bupivacaine, triamcinolone, and heparin. The study aimed to assess symptom improvement and changes in urinary frequency, nocturia, and bladder capacity, highlighting DMSO’s potential in managing bladder-related conditions4.

Risks and Considerations

Adverse Effects

While DMSO is generally well-tolerated, some studies have reported adverse effects. For instance, the unexpected increase in heel pressure ulcers suggests that DMSO’s effects can vary depending on the application site1. Additionally, although rare, some patients may experience undesired events during treatment, as noted in the study on acute tendopathies3.

Safety and Tolerability

Overall, DMSO is considered safe for topical use, with most studies reporting high tolerability among patients. However, it is crucial to monitor for any adverse reactions and adjust treatment protocols accordingly to minimize risks3.

Conclusion

DMSO is a valuable compound with diverse medical applications, from preventing viral infections to treating musculoskeletal and bladder conditions. However, its use must be carefully managed to avoid potential adverse effects, particularly in specific applications like pressure ulcer prevention. Further research is needed to fully understand the scope of DMSO’s benefits and risks in various medical contexts.

Disclaimer

The content presented in this blog is generated by Consensus, an AI-powered academic search engine, and is based on publicly available scientific literature. While every effort is made to provide accurate, up-to-date, and well-researched information, the content is intended for informational and educational purposes only. It does not constitute medical advice, diagnosis, or treatment. Always consult a qualified healthcare professional before making any decisions regarding medical conditions, treatments, or medications. The AI system’s analysis may not cover all perspectives, emerging research, or individual cases, and it is not a substitute for professional expertise. Neither the blog publisher nor the developers of the AI-powered search engine are responsible for any actions taken based on the information provided in this content. Use of this information is at your own risk. Citations to the original scientific studies are included for reference, but these studies should be reviewed in full and interpreted with the guidance of a healthcare or research professional.

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