What Is Testolone? Other Names: RAD 140, RAD-140, RAD140

What is Testolone?

This post was written with Consensus AI Academic Search Engine – please read our Disclaimer at the end of this article. Testolone, also known as RAD-140, is a selective androgen receptor modulator (SARM) that has garnered significant attention in the fields of sports medicine and bodybuilding. Unlike traditional anabolic steroids, SARMs like Testolone are designed to selectively target androgen receptors in muscle and bone tissues, potentially offering the benefits of anabolic steroids without the associated side effects.

Chemical Structure and Synthesis

Testolone is a non-steroidal compound that binds to androgen receptors with high affinity. Its chemical structure allows it to mimic the effects of testosterone, promoting muscle growth and bone density. The synthesis of Testolone involves complex organic chemistry techniques, including the conversion of precursor molecules through various chemical reactions.

Clinical Applications of Testolone

Muscle Wasting Diseases

Testolone has shown promise in the treatment of muscle wasting diseases such as sarcopenia and cachexia. By promoting muscle growth and preventing muscle loss, Testolone can improve the quality of life for patients suffering from these debilitating conditions.

Osteoporosis

Testolone’s ability to increase bone density makes it a potential treatment for osteoporosis. By strengthening bones, Testolone can reduce the risk of fractures and improve overall bone health.

Breast Cancer

Testolone has also been investigated for its potential in treating breast cancer. Aromatase inhibitors like testololactone have shown substantial activity against breast cancer, and Testolone’s selective action on androgen receptors may offer similar benefits3.

Research and Development

Microbial Formation and Hydrolysis

Research has shown that testolic acid, a related compound, is produced by the enzymatic hydrolysis of testololactone. This process involves the fermentation of androstenedione with microorganisms such as Cephalosporium acremonium1.

Hemisynthesis and Molecular Docking Studies

Recent studies have focused on the hemisynthesis of nitrogen-containing steroidal aromatase inhibitors, including testololactam and testolactam. These compounds have been synthesized from common phytosterols and have shown promising results in molecular docking studies with aromatase (CYP19), revealing their potential as therapeutic agents2.

Metabolism and Excretion

The metabolism of testololactone has been studied extensively. When administered to patients, testololactone is metabolized and excreted primarily through urine, with more than 96% of the radioactivity recovered within 72 hours4.

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Testolone Mechanism of Action

Testolone works by selectively binding to androgen receptors in muscle and bone tissues. This selective binding triggers anabolic activity, leading to increased muscle mass and strength. Unlike traditional anabolic steroids, Testolone does not convert to estrogen, thereby reducing the risk of estrogen-related side effects such as gynecomastia.

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Adverse Effects of Testolone

Metabolic Effects: Co-administration of 5α-reductase inhibitors (5aRIs) with glucocorticoids (GCs) can worsen adverse metabolic effects. This includes increased glucose production, decreased glucose utilization, and impaired insulin-mediated suppression of non-esterified fatty acids (NEFA) levels1.

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How has Testolone (RAD140) Improved Patient Outcomes?

Breast Cancer Treatment Efficacy

RAD140 has shown significant anti-tumor activity in AR/ER+ breast cancer models, outperforming fulvestrant in inhibiting tumor growth1.

When combined with CDK4/6 inhibitors (like palbociclib) or mTOR inhibitors (like everolimus), RAD140 further enhances anti-tumor efficacy in AR/ER+ breast cancer models1.

Skeletal Muscle and Health Impact

Long-term RAD140 supplementation in female mice increased frailty status and mortality risk, indicating potential adverse effects on overall health2.

RAD140 did not improve muscle strength or adaptive potential in ageing female mice, suggesting limited benefits for treating sarcopenia at the tested dosage2.

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Common Complaints Associated with Testolone Use

Lack of Efficacy in Specific Conditions: Mesterolone, another androgenic compound, was found to be ineffective in improving male fertility in the absence of defined endocrinopathy, suggesting that similar androgenic compounds like Testolone may also lack efficacy in certain conditions1.

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Disclaimer

The content presented in this blog is generated by Consensus, an AI-powered academic search engine, and is based on publicly available scientific literature. While every effort is made to provide accurate, up-to-date, and well-researched information, the content is intended for informational and educational purposes only. It does not constitute medical advice, diagnosis, or treatment. Always consult a qualified healthcare professional before making any decisions regarding medical conditions, treatments, or medications. The AI system’s analysis may not cover all perspectives, emerging research, or individual cases, and it is not a substitute for professional expertise. Neither the blog publisher nor the developers of the AI-powered search engine are responsible for any actions taken based on the information provided in this content. Use of this information is at your own risk. Citations to the original scientific studies are included for reference, but these studies should be reviewed in full and interpreted with the guidance of a healthcare or research professional.

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