10 papers analyzed
These studies suggest that obesity is influenced by multiple genes and their interactions with the environment, with both polygenic and rare monogenic forms contributing to the disease.
11 papers analyzed
Obesity is a complex and multifactorial condition influenced by both genetic and environmental factors. The genetic component of obesity has been extensively studied, revealing that multiple genes and their interactions play a significant role in predisposing individuals to obesity. This synthesis aims to summarize the key insights from various research papers on the genetic factors contributing to obesity.
Polygenic Nature of Obesity:
Monogenic Forms of Obesity:
Common Genetic Variants:
Gene-Environment Interactions:
Gene-Gene Interactions:
Heritability of Obesity:
Adipose Tissue Genes:
The research collectively indicates that obesity is a complex condition influenced by multiple genetic factors, both common and rare. While monogenic forms of obesity are rare, polygenic forms involving multiple genes are more common. The interaction between genetic predisposition and environmental factors, such as diet and physical activity, plays a crucial role in the development of obesity. Understanding these genetic factors and their interactions can provide valuable insights into the mechanisms underlying obesity and pave the way for more effective prevention and treatment strategies.
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